Sure you can, as long as you have the chemicals that you want to react, which can be quite tricky because space is pretty much empty!
So you need to get two chemicals together to hit eachother. This is even less likely because space is so cold that they don’t have the energy to move around very fast. BUT, if it did happen, then the chemical reaction would happen, just like it does on Earth!
Yes they do happen – for example before stars can form from hydrogen, the hydrogen has to turn into molecules of hydrogen (or it can’t cool down enough to collapse and form a proto-star).
We have detected quite complex molecules (like alcohol for example) in space. It’s just very cold out there, and the density of atoms is quite low, so everything takes a really long time.
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